Prof. Robert Clarke | Fortification | Nutritional Research Excellence Award
Prof. Robert Clarke | Fortification | Professor | University of Oxford | United Kingdom
Prof. Robert Clarke is an internationally recognized cancer researcher and academic administrator, currently serving as the Executive Director of The Hormel Institute and a Professor of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota. His education includes a BSc in Biological Sciences from Ulster University, and an MSc and PhD in Biochemistry from Queen’s University Belfast, which also awarded Prof. Robert Clarke a DSc in recognition of his professional work. Prof. Robert Clarke’s professional experience includes serving on the faculty and in administrative leadership roles at Georgetown University for many years before moving to the University of Minnesota. The primary research interest of Prof. Robert Clarke is in breast cancer, focusing on how hormones and related factors affect the disease and how tumors develop resistance to systemic therapies. His research skills encompass an integrative systems biology approach, utilizing genomics, bioinformatics, cell signaling, and molecular biology to study drug resistance and cell fate. Prof. Robert Clarke has received significant recognition, including being an elected Fellow of the American Association for the Advancement of Science (AAAS) and a Fellow of the Royal Society of Chemistry, Royal Society of Medicine, and Royal Society of Biology in the U.K. Prof. Robert Clarke’s extensive publication record and leadership in multinational research studies solidify his standing as a prominent figure driving advancements in cancer therapeutics.
Featured Publications:
Clarke, R., Brünner, N., Katzenellenbogen, B. S., Thompson E. W., Norman, M. J., Koppi, C., Paik, S., Lippman, M. E., & Dickson, R. B. (1989). Progression from hormone dependent to hormone independent growth in MCF-7 human breast cancer cells. Proceedings of the National Academy of Sciences USA, 86(10), 3649–3653. (1989) [1359 citations]
Trock, B. J., Leonessa, F., & Clarke, R. (1997). Multidrug resistance in breast cancer: A meta-analysis of MDR1/gp170 expression and its possible functional significance. Journal of the National Cancer Institute, 89(13), 917–931. (1997) [640 citations]
Clarke, R., Ressom, H. W., Wang, A., Xuan, J., Liu, M. C., Gehan, E. A., & Wang, Y. (2008). The properties of high-dimensional data spaces: Implications for exploring gene and protein expression data. Nature Reviews Cancer, 8(1), 37–49. (2008) [743 citations]
Dissociation between steroid receptor expression and cell proliferation in the human breast. (1997). Cancer Research, 57(22), 4987–4991. (1997) [857 citations]
Aberrant activation of notch signaling in human breast cancer. (2006). Cancer Research, 66(3), 1517–1525. (2006) [751 citations]
Meta-analysis of soy intake and breast cancer risk. (2006). Journal of the National Cancer Institute, 98(7), 459–471. (2006) [731 citations]
Tyson, J. J., Baumann, W. T., Chen, C., Verdugo, A., Tavassoly, I., Wang, Y., Weiner, L. M., & Clarke, R. (2011). Dynamic modelling of estrogen signaling and cell fate in breast cancer cells. Nature Reviews Cancer, 11(7), 523–532. (2011) [523 citations]