Seung Bum Park | Molecular Diversity | Best Researcher Award

Posted on 05/08/202410/08/2024 by sciencefatherLeave a Comment

Prof Dr. Seung Bum Park | Molecular Diversity | Best Researcher Award

Professor at Seoul National Universy, South Korea

Seung Bum Park is a renowned Professor and Director at the CRI Center for Chemical Proteomics in the Department of Chemistry at Seoul National University. His research focuses on chemical biology, drug discovery, and high-content phenotypic screening, utilizing diverse approaches to explore and manipulate biological systems. With a background in bioorganic chemistry, Park has made significant contributions to the understanding of molecular mechanisms and the development of innovative chemical tools for biomedical research.

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Seung Bum Park has a distinguished record of research output, with numerous publications in high-impact journals. His work is frequently cited, reflecting his influence in the fields of chemical biology and drug discovery. His author metrics, including citations and h-index, highlight his contributions to advancing scientific knowledge and his impact on the research community.

Citations: Park’s work has garnered 8,232 citations, illustrating the impact and relevance of his research within the scientific community.
Documents: He has published 168 documents, including research papers, reviews, and contributions to scientific literature.
h-index: With an h-index of 45, Park has a substantial number of publications that have been widely cited, indicating both the quality and quantity of his research output.

Education

Seung Bum Park completed his Ph.D. in Bioorganic Chemistry at Texas A&M University under the mentorship of Prof. Robert F. Standaert, where he was awarded the Boehringer-Ingelheim Fellowship. He holds an M.S. in Organic Chemistry and a B.S. in Chemistry, both from Yonsei University, where he graduated summa cum laude. His educational background underscores a strong foundation in both organic and bioorganic chemistry.

Research Focus

Park’s research interests are broad and interdisciplinary, encompassing chemical biology, diversity-oriented synthesis, drug discovery, and fluorescent bioimaging. His work aims to identify new drug targets and develop chemical probes to elucidate complex biological processes. His research integrates high-content phenotypic screening and target identification, striving to advance therapeutic development and understand disease mechanisms at a molecular level.

Professional Journey

Park’s professional journey includes notable positions across prestigious institutions. He currently serves as a Professor at Seoul National University, where he has held various academic roles since 2004. His experience also includes postdoctoral work at Harvard University as a Howard Hughes Medical Institute Fellow and a visiting professorship at The Scripps Research Institute. His career reflects a strong commitment to research excellence and academic leadership.

Honors & Awards

Seung Bum Park has received numerous honors and awards for his contributions to science and research. These include the Science and Technology Medal of Honor from the Korean Government, the Presidential Young Scientist Award, and several research excellence awards from Seoul National University and other institutions. His accolades recognize his innovative research and leadership in the scientific community.

Publications Noted & Contributions

Park has authored and co-authored over 195 research papers, with notable contributions to journals such as Cell, Angewandte Chemie, and ACS Chemical Biology. His work covers a range of topics from bioorthogonal chemistry to molecular degradation strategies, highlighting his expertise and impact in chemical biology. His publications are influential, contributing significantly to the advancement of scientific knowledge in his field.

1. Inflachromene Ameliorates Parkinson’s Disease by Targeting Nrf2-Binding Keap1

Journal: Chemical Science
Year: 2024
DOI: 10.1039/D3SC06997D
Contributors: Junhyeong Yim, Yoon Soo Hwang, Jae-Jin Lee, Ju Hee Kim, Jeong Yeob Baek, Jaeyeong Jeong, Young Il Choi, Byung Kwan Jin, Seung Bum Park
Summary: This paper explores how Inflachromene, a chemical compound, impacts Parkinson’s disease by targeting and modulating the Nrf2-binding protein Keap1. The study provides insights into potential therapeutic strategies for neurodegenerative diseases.

2. Unveiled Reactivity of Masked Diformylmethane with Enamines Forming Resonance-Assisted Hydrogen Bonding Leads to Di-Meta-Substituted Pyridines

Journal: Communications Chemistry
Year: 2024-06-28
DOI: 10.1038/s42004-024-01228-w
Contributors: Sihyeong Yi, Ji Hyae Lee, Hana Cho, Kannan Vaithegi, Dawon Yi, Sijun Noh, Seung Bum Park
Summary: The research details the reaction of masked diformylmethane with enamines, leading to the formation of di-meta-substituted pyridines. The study highlights the role of resonance-assisted hydrogen bonding in this chemical process.

3. Rational Design of Pyrido[3,2-b]indolizine as a Tunable Fluorescent Scaffold for Fluorogenic Bioimaging

Journal: JACS Au
Year: 2024-06-10
DOI: 10.1021/jacsau.4c00135
Contributors: Sihyeong Yi, Dahham Kim, Wansang Cho, Jung Ho Lee, Ji Hoon Kwon, Jonghoon Kim, Seung Bum Park
Summary: This publication presents the design of a pyrido[3,2-b]indolizine scaffold with tunable fluorescent properties for bioimaging applications. The study demonstrates the potential of this scaffold in developing advanced fluorescent probes.

4. Unveiling the Concealed Reactivity of Masked Diformylmethane with RAHB-Assisted Enamines Leads to Dissymmetric Di-Meta-Substituted Pyridines

Preprint: 2024-03-18
DOI: 10.21203/rs.3.rs-4020381/v1
Contributors: Seung Bum Park, Sihyeong Yi, Ji Hyae Lee, Hana Cho, Kannan Vaithegi, Dawon Yi, Sijun Noh
Summary: This preprint discusses the reaction mechanisms involving masked diformylmethane and resonance-assisted hydrogen bonding (RAHB) with enamines, leading to the formation of dissymmetric di-meta-substituted pyridines.

5. Ultrafluorogenic Monochromophore-Type BODIPY-Tetrazine Series for Dual-Color Bioorthogonal Imaging with a Single Probe

Journal: Angewandte Chemie
Year: 2023-12-21
DOI: 10.1002/ange.202316220
Contributors: Dahham Kim, Hayoung Son, Seung Bum Park
Summary: The article presents a series of ultrafluorogenic BODIPY-tetrazine probes designed for dual-color bioorthogonal imaging. The study demonstrates the utility of these probes in complex biological imaging applications.

Research Timeline

Over his career, Park has been involved in groundbreaking research projects and has made substantial contributions to his field. His research timeline includes pivotal studies on chemical probes, drug discovery, and phenotypic screening. Key milestones in his career include his tenure at Harvard, his leadership roles at Seoul National University, and his ongoing research in chemical proteomics.

Collaborations and Projects

Park’s research involves collaborations with leading institutions and researchers worldwide. His projects often include partnerships with organizations such as The Scripps Research Institute and the Genomic Institute of Novartis Foundation. His collaborative efforts extend to various international conferences and research initiatives, reflecting his active engagement in global scientific communities and projects.

Strengths of the Best Researcher Award

Innovative Research Contributions
- Prof. Dr. Seung Bum Park has made significant advancements in chemical biology and drug discovery, as demonstrated by his research on Inflachromene’s potential for treating Parkinson’s disease and his design of new fluorescent scaffolds for bioimaging. His work not only advances scientific understanding but also has practical applications in medicine.
High Research Impact
- With over 8,200 citations and an h-index of 45, Park’s research has had a profound impact on the scientific community. His high citation count reflects the relevance and influence of his work in chemical biology and drug discovery.
Diverse Research Portfolio
- Park’s research spans various fields, including chemical biology, drug discovery, and fluorescent bioimaging. This diverse portfolio highlights his ability to address complex scientific questions from multiple angles, showcasing his versatility and breadth of expertise.
Academic Leadership and Recognition
- As a professor and director at the CRI Center for Chemical Proteomics, Park has demonstrated leadership in both research and education. His numerous awards, including the Science and Technology Medal of Honor and the Presidential Young Scientist Award, underscore his recognition and respect within the scientific community.
Strong Collaborative Network
- Park’s collaborations with leading institutions such as Harvard University and The Scripps Research Institute exemplify his active engagement in the global scientific community. These partnerships enhance the scope and impact of his research, fostering innovation and knowledge exchange.

Areas for Improvement

Broader Public Engagement
- While Park’s research is highly specialized, increasing efforts to communicate scientific findings to the public could enhance the broader impact of his work. Engaging in outreach activities and public science communication could help bridge the gap between scientific research and societal benefit.
Interdisciplinary Integration
- Expanding research efforts to integrate more disciplines could further enhance the applicability of Park’s work. Collaborating with experts in fields such as computational biology, materials science, or environmental science might open new avenues for research and innovation.
Focus on Translational Research
- Although Park’s research has significant implications for drug discovery, emphasizing translational research—moving discoveries from the lab to clinical settings—could accelerate the development of new therapies and improve patient outcomes.
Increased Focus on Emerging Technologies
- Incorporating emerging technologies, such as artificial intelligence and machine learning, into research methodologies could enhance data analysis and interpretation. Adopting these technologies might provide new insights and streamline research processes.
Expansion of Research Topics
- Diversifying research topics to include emerging areas such as personalized medicine or regenerative medicine could broaden the impact of Park’s work. Exploring these cutting-edge fields could address new challenges and opportunities in biomedical research.

Conclusion

Prof. Dr. Seung Bum Park’s recognition as a Best Researcher highlights his outstanding contributions to chemical biology, drug discovery, and bioimaging. His innovative research, high impact, and leadership in the field underscore his prominence in the scientific community. While his achievements are impressive, there are opportunities to further enhance the reach and applicability of his work. By increasing public engagement, integrating interdisciplinary approaches, focusing on translational research, adopting emerging technologies, and expanding research topics, Park can continue to make significant strides in advancing scientific knowledge and addressing critical challenges in biomedical research.

György Keglevich | Green Chemistry | Green Chemistry Award

Posted on 03/08/202409/08/2024 by sciencefatherLeave a Comment

Prof Dr. György Keglevich | Green Chemistry | Green Chemistry Award

Professor at Dept of Organic Chemistry and Technology, Budapest University of Technology and Economics, Hungary

György Keglevich is a distinguished chemist specializing in organophosphorus chemistry. He is a Full Professor at the Department of Organic Chemistry and Technology at Budapest University of Technology and Economics. With a career spanning several decades, Keglevich has made significant contributions to the field through his research, publications, and mentoring of future scientists. His work encompasses a wide range of topics in chemical synthesis, green chemistry, and practical applications of his research.

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György Keglevich is a prominent researcher affiliated with the Budapest University of Technology and Economics in Budapest, Hungary. He has made significant contributions to the field, with a notable citation count of 9,463 across 590 documents. His h-index is 43, reflecting the impact and influence of his work in the academic community.

Education

Keglevich graduated from the Technical University of Budapest (TUB) in 1981 with a degree in chemical engineering. He obtained his PhD and Doctor of Chemical Science degrees in organophosphorus chemistry and earned his “Dr Habil.” degree in 1995. His early academic career included research at Duke University under the guidance of Professor Louis D. Quin.

Research Focus

Keglevich’s research primarily revolves around organophosphorus chemistry, including the development of P-heterocyclic compounds, ring enlargement of five-membered P-heterocycles, and the synthesis of bridged P-heterocycles. His work also explores the reactivity of aromatic phospholes, phosphine-transition metal complexes, and green chemistry practices such as microwave-assisted reactions and the use of ionic liquids.

Professional Journey

Keglevich began his career as a research employee at the Chinoin Pharmaceutical Factory before joining TUB’s Department of Organic Chemical Technology as an Assistant Professor in 1982. He was promoted to Associate Professor in 1993 and became a Full Professor in 1996. He has held leadership roles within his department, including serving as Head from 1999 to 2021. He has also been a Visiting Associate Professor at the University of Massachusetts on multiple occasions.

Honors & Awards

Keglevich has received several prestigious awards, including the Award of the Hungarian Academy of Sciences in 2004. In 2021, he was honored with the state decoration of Knight-Cross for Hungarian Order, and in 2022, he received the József Palatine Prize from Budapest University of Technology. These accolades recognize his significant contributions to the field of chemistry.

Publications Noted & Contributions

Keglevich has made substantial contributions through his publications, which include around 651 papers, 51 book chapters, and two books. His research is noted for advancements in the Hirao reaction, catalyst-free P–C coupling reactions, and microwave-assisted direct esterification. His contributions have been influential in developing new methods and applications in chemistry.

N-Functionalization of β-Aminophosphonates: Cytotoxic Effects of the New Derivatives

Journal: Organic & Biomolecular Chemistry

Year: 2024

DOI: 10.1039/D4OB00243A

Contributors: György Keglevich, Petra Regina Varga, Emőke Dinnyési, Zsuzsanna Szalai, Szilvia Bősze, Oláhné Szabó Rita, László Drahos, Konstantin Karaghiosoff

Synthesis of Mesylated and Tosylated α-Hydroxy-Benzylphosphonates; Their Reactivity and Cytostatic Activity

Journal: ACS Omega

Date: July 16, 2024

DOI: 10.1021/acsomega.4c04382

Contributors: Zsuzsanna Szalai, Márton Debrei, Péter Ábrányi-Balogh, Szilvia Bősze, Rita Oláhné Szabó, Konstantin Karaghiosoff, László Drahos, György Keglevich

Microwave-Assisted, Ionic Liquid-Catalyzed Aminolysis and Alcoholysis of Phosphinic Derivatives: The Interconversion of Phosphinates and Phosphinic Amides

Journal: Green Chemistry

Year: 2023

DOI: 10.1039/D3GC02711B

Contributors: György Keglevich, Nikoletta Harsági, Sarolta Szilágyi

New N-Acyl- as well as N-Phosphonoylmethyl- and N-Phosphinoylmethyl-α-Amino-Benzylphosphonates by Acylation and a Tandem Kabachnik–Fields Protocol

Journal: Organic & Biomolecular Chemistry

Year: 2023

DOI: 10.1039/D3OB00010A

Contributors: Petra Regina Varga, Konstantin Karaghiosoff, Éva Viktória Sári, András Simon, László Hegedűs, László Drahos, György Keglevich

Synthesis and Anticancer Activity of Phosphinoylated and Phosphonoylated N-Heterocycles Obtained by the Microwave-Assisted Palladium Acetate-Catalyzed Hirao Reaction

Journal: Chemistry – A European Journal

Date: December 6, 2023

DOI: 10.1002/chem.202302465

Contributors: Bianka Huszár, Renáta Szolga, Szilvia Bősze, Rita Oláhné Szabó, András Simon, Konstantin Karaghiosoff, Mátyás Czugler, László Drahos, György Keglevich

Research Timeline

Keglevich’s research career began in the early 1980s with a focus on chemical synthesis and organophosphorus chemistry. Over the decades, he has developed and refined methodologies in green chemistry and practical applications. His research timeline includes significant milestones such as his promotion to Full Professor in 1996 and his ongoing work in innovative chemistry practices.

Collaborations and Projects

Keglevich has collaborated on numerous projects related to organophosphorus chemistry and green chemistry. His industrial projects include the synthesis of pharmaceutical intermediates and products, which are reflected in his three patents. He has also engaged in various academic collaborations, contributing to advancements in both theoretical and practical aspects of chemistry.

György Keglevich has authored or co-authored approximately 651 papers, including 51 book chapters and two books. His research output has earned him an h-index of 48, reflecting his significant impact in the field of chemistry. His publications are highly regarded, indicating a strong influence in organophosphorus and green chemistry research.

Strengths of the Green Chemistry Award for Prof. Dr. György Keglevich

Significant Contributions to Green Chemistry: Prof. Keglevich’s research emphasizes green chemistry practices, including microwave-assisted reactions and the use of ionic liquids. These contributions align well with the principles of green chemistry, aiming to make chemical processes more sustainable and environmentally friendly.
Innovative Methodologies: His work on catalyst-free P–C coupling reactions, microwave-assisted esterification, and ionic liquid-catalyzed reactions demonstrates a commitment to developing new, more efficient, and eco-friendly chemical processes.
Extensive Publication Record: With over 651 papers and numerous contributions to high-impact journals, Prof. Keglevich’s extensive publication record showcases his deep engagement with and impact on the field of green chemistry.
High Citation Count: An h-index of 48 and a citation count of 9,463 indicate that his research is highly influential and well-regarded within the academic community. This metric underscores the relevance and importance of his work in advancing green chemistry.
Recognition and Awards: The numerous awards and honors, including the Knight-Cross for Hungarian Order and the József Palatine Prize, affirm his significant impact and contributions to chemistry, reinforcing his candidacy for the Green Chemistry Award.

Areas for Improvement

Broader Impact on Industry: While Prof. Keglevich’s research is highly influential academically, showcasing a broader impact on industrial applications could strengthen his case for the Green Chemistry Award. Highlighting how his methodologies have been adopted or commercialized would be beneficial.
Integration with Emerging Green Technologies: There could be a more explicit connection to emerging green technologies such as renewable energy solutions or advanced recycling methods. Emphasizing how his work integrates with or contributes to these areas might enhance his profile.
Interdisciplinary Collaborations: Expanding collaborations beyond organophosphorus chemistry to include other disciplines such as materials science or environmental engineering could demonstrate a more comprehensive approach to solving green chemistry challenges.
Public Engagement and Outreach: Increasing efforts in public engagement, science communication, and education could further highlight the societal impact of his research. Showcasing initiatives that aim to educate and inspire the next generation of chemists could add value.
Future Research Directions: Outlining specific future research directions and how they align with the evolving goals of green chemistry could provide a forward-looking perspective. This might include exploring new green solvents, reaction conditions, or sustainable practices.

Conclusion

Prof. Dr. György Keglevich is a leading figure in green chemistry with a distinguished record of innovative research, extensive publications, and significant contributions to sustainable chemical practices. His work on eco-friendly methodologies and high-impact research underscores his qualifications for the Green Chemistry Award. Addressing areas for improvement, such as demonstrating broader industrial impact and engaging with emerging green technologies, could further strengthen his candidacy. Overall, his accomplishments and recognition in the field make him a strong contender for the award, reflecting his dedication to advancing green chemistry and its practical applications.

Yuan Yao | Organic Geochemistry | Best Researcher Award

Posted on 03/08/202409/08/2024 by sciencefatherLeave a Comment

Dr. Yuan Yao | Organic Geochemistry | Best Researcher Award

Doctorate at Xi’an Jiaotong University, China

Yuan Yao is an Associate Professor at the Institute of Global Environmental Change, Xi’an Jiaotong University. With a robust background in organic geochemistry and paleoclimate studies, Yao has established himself as a prominent researcher in understanding climate change through geochemical methods.

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Yuan Yao’s scholarly impact is evident through his publication record, with 26 SCI papers and an H-index of 19. His high citation count reflects the significant influence and recognition of his research within the scientific community.

Citations: 354
Documents: 25
h-index: 12

Education

Yuan Yao’s educational journey includes a Ph.D. in Earth and Environmental Sciences from Xi’an Jiaotong University, an M.S. in the same field from the same institution, and a B.E. from Northwest A&F University. His advanced education has provided a strong foundation for his research career.

Research Focus

Yao’s research revolves around organic and isotope geochemistry, focusing on how lipid biomarkers like alkenones and GDGTs serve as proxies for paleoclimate studies. His work aims to enhance understanding of historical climate conditions and changes in lake salinity.

Professional Journey

Yao’s career path includes roles as a Postdoctoral Researcher at the Chinese Academy of Sciences and Brown University before becoming an Associate Professor at Xi’an Jiaotong University. This trajectory highlights his extensive experience and expertise in his field.

Honors & Awards

Yuan Yao has been recognized with editorial roles in journals such as Frontiers, Earth Sciences, and Water, reflecting his standing in the academic community. These positions underscore his contributions and influence in the field of geochemistry and climate science.

Publications Noted & Contributions

Yao has authored 26 SCI papers with key publications in renowned journals like Geology and Geochimica et Cosmochimica Acta. His research on lipid biomarkers has significantly advanced paleoclimate research, particularly in understanding historical temperature and salinity changes.

Pre‐Industrial (1750–1850 CE) Cold Season Warmth in Northeastern China

Journal: Geophysical Research Letters
Publication Date: May 28, 2023
DOI: 10.1029/2023GL103591
Contributors: Yuan Yao, Lu Wang, Yongsong Huang, Jie Liang, Richard S. Vachula, Yanjun Cai, Hai Cheng

Unexpected Cold Season Warming During the Little Ice Age on the Northeastern Tibetan Plateau

Journal: Communications Earth & Environment
Publication Date: May 26, 2023
DOI: 10.1038/s43247-023-00855-w
Contributors: Yuan Yao, Lu Wang, Xiangzhong Li, Hai Cheng, Yanjun Cai, Richard S. Vachula, Jie Liang, Hanying Li, Guangxin Liu, Jingyao Zhao et al.

Group 1 Phylogeny and Alkenone Distributions in a Freshwater Volcanic Lake of Northeastern China: Implications for Paleotemperature Reconstructions

Journal: Organic Geochemistry
Publication Date: August 2022
DOI: 10.1016/j.orggeochem.2022.104483
Contributors: Yuan Yao

Calibration and Application of Branched GDGTs to Tibetan Lake Sediments: The Influence of Temperature on the Fall of the Guge Kingdom in Western Tibet, China

Journal: Paleoceanography and Paleoclimatology
Publication Date: May 2022
DOI: 10.1029/2021PA004393
Contributors: Jie Liang, Yanlong Guo, Nora Richter, Haichao Xie, Richard S. Vachula, Rachel L. Lupien, Boyang Zhao, Mingda Wang, Yuan Yao, Juzhi Hou et al.

Lipid Biomarkers in Lake Wudalianchi Record Abrupt Environmental Changes from the Volcanic Eruption in 1776

Journal: Organic Geochemistry
Publication Date: February 2022
DOI: 10.1016/j.orggeochem.2021.104349
Contributors: Yuan Yao

Research Timeline

Yao’s research timeline includes his current role as Associate Professor since December 2019, previous postdoctoral positions from August 2016 to November 2019, and his earlier doctoral and master’s studies. This timeline illustrates his progressive academic and research career.

Collaborations and Projects

Yao has collaborated with institutions such as Brown University and has been involved in 8 National Foundation projects. These collaborations and projects have played a crucial role in advancing research in organic geochemistry and paleoclimate.

Strengths of the Best Researcher Award for Yuan Yao

Significant Scholarly Impact: Yuan Yao’s high citation count (354) and H-index (12) reflect his substantial influence and recognition in the field of organic geochemistry. His research has notably advanced our understanding of paleoclimate studies through innovative geochemical methods.
Impressive Publication Record: With 26 SCI papers, Yao has demonstrated a consistent output of high-quality research. His work has been published in prestigious journals like Geophysical Research Letters, Communications Earth & Environment, and Organic Geochemistry, underscoring the relevance and impact of his contributions.
Expertise in Paleoclimate Studies: Yao’s research focus on lipid biomarkers and isotope geochemistry has led to significant findings in paleoclimate reconstructions. His studies on historical temperature and salinity changes provide valuable insights into past climate conditions.
Notable Research Contributions: Key publications, such as those on pre-industrial cold season warmth and unexpected warming during the Little Ice Age, highlight Yao’s role in addressing important climate science questions. His work on branched GDGTs and lipid biomarkers further contributes to understanding environmental changes.
Established Professional Trajectory: Yao’s career progression from postdoctoral research to his current role as an Associate Professor reflects a well-established academic path. His experience with institutions like the Chinese Academy of Sciences and Brown University adds to his credibility and expertise.

Areas for Improvement

Expand Citation Metrics: Although Yao’s citation count is commendable, further increasing his citations could enhance his visibility and influence. This could be achieved through broader dissemination of his work and collaborations with researchers in related fields.
Increase H-index: An H-index of 12 is strong but could be improved. Continued publication in high-impact journals and participation in high-profile research projects could contribute to a higher H-index.
Diversify Research Topics: While Yao’s focus on lipid biomarkers and paleoclimate studies is impressive, exploring additional areas within geochemistry or interdisciplinary research could broaden the scope of his contributions and attract a wider audience.
Enhance Public Engagement: Increasing public engagement through popular science articles, presentations at conferences, and collaborations with media could help raise awareness of Yao’s research and its significance to a broader audience.
Broaden Collaborative Network: Expanding collaborations beyond existing institutions and engaging with international research groups could introduce new perspectives and opportunities for joint projects, further advancing Yao’s research impact.

Conclusion

Yuan Yao’s accomplishments in organic geochemistry and paleoclimate research position him as a deserving candidate for the Best Researcher Award. His significant scholarly impact, impressive publication record, and expertise in understanding historical climate changes highlight his contributions to the field. By addressing areas for improvement, such as increasing citation metrics and broadening research topics, Yao can further enhance his influence and continue to make valuable contributions to the scientific community.